Wednesday, August 31, 2005

Is valium or xanax alcohol in pill form?

Benzodiazepines: Specific competitors for the binding of l-tryptophan to human serum albumin
W. E. Müller1 and U. Wollert1

(1) Pharmakologisches Institut der Universität Mainz, Obere Zahlbacher Straße 67, D-6500 Mainz, Federal Republic of Germany

Received: 24 December 1974 Accepted: 5 February 1975

Summary By means of the gel filtration technique, the effect of nine benzo-diazepine derivates on the binding of l-tryptophan to human serum albumin was investigated. Using equimolar tryptophan and benzodiazepine concentrations, all benzodiazepines with binding constants higher than 104 (M–1), displace l-tryptophan from its binding site to a high degree. The mechanism of the displacement was characterized as a competition for a common binding site. Some of the benzodiazepines displace l-tryptophan to a greater extent than salicylic acid. The benzodiazepines and tryptophan are the only substances known with a high degree of stereospecific binding to human serum albumin. This study shows that there is only one binding site on the human serum albumin molecule, which binds tryptophan and the benzodiazepines in a highly stereospecific manner. Therefore it is concluded that the benzodiazepines and l-tryptophan must have similarities in their molecular structure, so that both can bind to the common binding site in such specific manner. These considerations are discussed in regard to the known influence of benzodiazepine derivatives on the l-tryptophan metabolism in brain. A direct involvement of the reported displacement in the pharmacological actions of the drugs seems not to be relevant because of their small therapeutical plasma levels.

A Drink A Day Keeps Tryptophan Levels High?

Yes it does! Is this the reason so many studies show drinking alcohol daily in moderation is good for you? Probably, but don't wait for the Big Pharma Companies to tell you. This is just one of many drugs (yes alcohol is a drug) that cause an increase in tryptophan in the human brain and body.